Publications

The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production.
Feng Z#, Wang L#, Chen S, Cao S, Lei M, Yang X, Ma K, Yu S, Hu H, Zheng K, Xu X, Zheng Q, Wang S, Hu W, Lim CY.*
The EMBO Journal, 2026, 45 (4), 1136–1174.

Architecture of the Human KICSTOR and GATOR1–KICSTOR Complexes.
Teng F, Zeng H, Mai X, Chen S, Wang L, Feng Z, Tian S, Wang S, Stjepanovic G*, Lim CY*, Su MY.*
Nature Structural & Molecular Biology, 2025, 32 (12), 2587–2600.

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R.*
Science, 2022, 377 (6612), 1290–1298.

Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
Shrestha MM, Lim CY, Bi X, Robinson RC, Han W.*
Frontiers in Endocrinology, 2021, 12, 653557.

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R.*
Developmental Cell, 2021, 56 (3), 260–276.

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C.
Lim CY, Davis O, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.*
Nature Cell Biology, 2019, 21 (10), 1206–1218.

Structural mechanisms of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R.*
Science, 2019, 366 (6468), 971–977.

A unified approach to targeting the lysosome's degradative and growth signaling roles.
Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.*
Cancer Discovery, 2017, 7 (11), 1266–1283.

The lysosome as a command and control center for cellular metabolism.
Lim CY, Zoncu R.*
Journal of Cell Biology, 2016, 214 (6), 653–664.

Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.
Lim CY, Bi XZ, Wu D, Kim JB, Gunning PW, Hong W, Han W.*
Nature Communications, 2015, 6 (1), 1–15.

Adiponectin is released via a unique regulated exocytosis pathway from a pre-formed pool of vesicles upon insulin stimulation.
Lim CY, Hong W, Han W.*
Biochemical Journal, 2015, 471 (3), 381–389.

Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation.
Kim JI, Huh JY, Sohn JH, Choe SS, Lee YS, Lim CY, Jo A, Park SB, Han W, Kim JB.*
Molecular and Cellular Biology, 2015, 35(10), 1686–1699.

Tropomodulin3 as the link between insulin-activated Akt2 and cortical actin remodeling in preparation of GLUT4 exocytosis.
Lim CY, Han W.*
Bioarchitecture, 2014, 4 (6), 210–214.

Arp2/3 complex regulates adipogenesis by controlling cortical actin remodeling.
Yang W, Thein S, Lim CY, Ericksen RE, Sugii S, Xu F, Robinson RC, Kim JB, Han W.*
Biochemical Journal, 2014, 464 (2), 179–192.

Insulin-stimulated leptin secretion requires calcium and PI3K-Akt activation.
Wang Y, Ali Y, Lim CY, Hong W, Pang Z, Han W.*
Biochemical Journal, 2014, 458 (3), 491–498.

Neonatal Overnutrition in the Mice Exacerbates High Fat Diet Induced Metabolic Perturbations.
Liu Z#, Lim CY#, Su MY#, Soh SL, Shui G, Wenk MR, Grove K, Radda GK, Han W, Xiao X.*
Journal of Endocrinology, 2013, 219 (2), 131–143.

Glucose Intolerance and Impaired Insulin Secretion in Pancreas-Specific Signal Transducer and Activator of Transcription-3 Knockout Mice Are Associated with Microvascular Alterations in the Pancreas.
Kostromina E, Gustavsson N, Wang X, Lim CY, Radda GK, Li C, Han W.*
Endocrinology, 2010, 151 (5), 2050–2059.

FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1.
Yang G, Lim CY, Li C, Xiao X, Radda GK, Li C, Cao X, Han W.*
Journal of Biological Chemistry, 2009, 284 (6), 3719–3727.

ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain binding.
Ang BK, Lim CY, Koh SS, Sivakumar N, Taib S, Lim KB, Ahmed S, Rajagopal G, Ong SH.*
Journal of Molecular Signaling, 2007, 2 (1), 1.