https://www.limlab.one/work daily 1.0 2026-01-25 https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/83ee0b3a-95ec-40f6-add2-e70483ad0fc8/1_D4H-mCh-hs-NPC1%2BT192_TetOn_2hr_w0001.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/d2a3f1ef-2cff-44bc-a911-6b64548da8a6/Experiment-4635-20_h0s0t0z0c0-2x0-5632y0-3789.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/a6c50a63-430f-467e-a6fd-197912c6724c/HeLa-sgNT_GFP-Parkin_CCCP_2024-04-29_17.17.57_deconvolved_2024-04-30T17-35-39.209.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/7a40cb8d-53a2-4717-be03-023ed91d8218/HeLa-sgNT_GFP-Parkin_Mock_2024-04-29_18.29.27_deconvolved_2024-05-01T16-29-34.096.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/0bef1ec8-10b7-436a-abf9-ff03e92aff1f/living+cell+Hela+DKOVAPA%26B2-6-4%2BmBaojinVAPB+PS+mitotracker_2025-04-01_15.39.17_deconvolved_2025-04-12T12-17-16.837.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/e75ca61e-7a1c-4693-8811-362cdbe17208/HeLa-GFP-Parkin_mock_2024-03-26_14.42.43_2024-03-26T22-24-02.286.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/44a71e72-b5aa-4be7-962d-232b6c94046f/demo_iNeurons_b3-Tubulin-100x+copy+2.jpg Research https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/2fd4c24d-56d6-43f8-80dc-c796677b0081/lysosomal+control+of+innate+immunity.png Research - Make it stand out Our latest study reveals a novel, parallel pathway for interferon (IFN) induction centered on the lysosomal LAMTOR-Rag complex. Distinct from canonical PRR signaling, this axis pre-conditions the IFN response by regulating IRF transcription factor levels and, through FLCN-mediated recruitment, activates a specific pool of p38 MAPK at the lysosome to stabilize Ifnb1 mRNA. By integrating these two essential functions—transcriptional priming and post-transcriptional stabilization—the lysosome acts as a critical metabolic checkpoint, where nutrient-sensing via the Rag GTPase cycle ensures IFN production is matched to cellular resources. This represents an evolutionary co-option of an ancient organellar signaling module for advanced vertebrate immunity (EMBO J, 2026). https://www.limlab.one/publications daily 0.75 2026-03-02 https://www.limlab.one/contact daily 0.75 2024-11-22 https://www.limlab.one/news daily 0.75 2026-03-02 https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/95b258f1-8fe2-47a8-8913-61a3e00ef49c/Screenshot+2025-11-11+at+10.36.46.png https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/190660cd-533d-44e2-88be-105883c03313/IMG_6832.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/a88fd3b5-778b-4879-ae1e-f08debb422c5/IMG_6586.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/02e41918-f881-4706-94af-b02c42f06d7d/IMG_6123.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/aa88fae0-4167-4fcd-bfb1-6873050991f6/Screenshot+2026-01-23+at+17.51.51.png https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/9d402e7c-5eeb-47ff-aa2e-a64faa992d07/IMG_6116.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/7489d35a-ad08-42d2-9e87-3f379cf6eda9/IMG_6110.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/e4a00208-455b-4dc6-abca-8d9f384fd82f/IMG_5108.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/9ad6bab6-737b-42a4-8171-618588c8bf3e/IMG_4370.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/651f0a25-f95c-4bca-b85f-9737b215efbb/IMG_4395.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/09736bb9-08ae-4860-8e93-786df557a2ee/Screenshot+2023-06-16+at+15.30.45.png https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/7a815bd5-ca44-46f5-b685-b040a8326bb3/IMG_3422.JPG https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/8eb63e6c-761a-4ee0-8477-014b7b3631ba/IMG_3051.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/48de441a-49f0-4e43-a646-824fa87fa15a/National_Natural_Science_Foundation_of_China_logo.png https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1615372645018-PQX1CFYR21BG6PIQRCNA/IMG_1008.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1615372895753-R2WL8OWHG8XTUQBQ8P03/IMG_1001.jpg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/b7aa053e-18cd-42d6-8bd5-ecb059ecd7be/IMG_5109.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/fdb6e603-71cf-4d98-9f5d-2893e2144ec8/WhatsApp+Image+2023-12-05+at+05.35.06.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1609817584097-573O9D42MBRHCCZIDLAN/IMG_0729.JPG https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/9a7996f4-ddcd-4505-a5be-a74bd95c64bf/IMG_6120.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/3041d34a-cd90-4c82-a068-3441301c5f39/WechatIMG5890.jpg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1606097354154-NZG1MMVBP3LQR19R1Z8U/IMG_0570.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1bce2329-f33d-4941-b045-6d32904f86c9/IMG_6119.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/c2e2cd0c-eca2-4daf-8783-af1fa3f6af53/IMG_5143.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1606097438446-PLR25FFEKYK9QSQH415J/IMG_0599.jpeg https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1618795524878-AVCMOHSA7HJZLH6IMRMQ/WechatIMG1069.jpeg News https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1618795571705-AJRKGH0INANML8MRW55D/IMG_1209.jpeg News https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1618795575750-L28LENW89D44ZBGE5G63/IMG_1228.jpeg News https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1618795576911-4EASPVDYEBW2WFZXFP3K/IMG_1320.jpeg News https://www.limlab.one/people daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/5ebb782584aa6d54ec2a8a6b/1bd98b1c-3f1a-424e-bfa1-5ff320c0c5ca/limlab_members_2025.12.31.png